Amvasc Plus

Amvasc Plus

Manufacturer:

Amherst Lab

Distributor:

Therapharma
Concise Prescribing Info
Contents
Per 5/12.5 mg tab Amlodipine besilate 5 mg, hydrochlorothiazide 12.5 mg. Per 10/12.5 mg tab Amlodipine besilate 10 mg, hydrochlorothiazide 12.5 mg
Dosage/Direction for Use
One 5/12.5 mg tab once daily. May be increased to 10/12.5 mg tab once daily.
Contraindications
Hypersensitivity to amlodipine besilate, hydrochlorothiazide or other sulfonamide derivatives. Advanced aortic stenosis, severe hepatic impairment &/or cholestasis, anuria & renal impairment, gout &/or hyperuricemia. History of cardiogenic shock. Women of childbearing potential. Pregnancy & lactation.
Special Precautions
Infants & childn. Elderly. Amlodipine: Severe aortic stenosis & obstructive coronary disease. Gradual reduction & w/drawal of the β-blocker dose. Hepatic & heart failure. Hydrochlorothiazide: Monitor serum electrolytes regularly. Symptomatic hypotension, severe renal disease. Hepatic disease or progressive liver disease. History of allergy or bronchial asthma. Exacerbation or activation of SLE. May impair glucose tolerance. Discontinue use before taking parathyroid function test. Hyperuricemia, hypomagnesemia.
Adverse Reactions
Fatigue, insomnia, dizziness, vertigo, headache, paresthesia, hypotension, hyperglycemia, impotence, thrombocytopenia, leukopenia, purpura, alopecia, urticaria, rash, erythema multiforme, muscle cramps, anorexia, pancreatitis, nausea, vomiting, constipation, diarrhea. Amlodipine: Asthenia, malaise, pain; hypertonia, hypoesthesia, peripheral neuropathy, tremor, mood changes, somnolence, nervousness, depression, abnormal dreams, anxiety, depersonalization; syncope, vasculitis, palpitations, MI, arrhythmia, tachycardia, flushing, edema, chest pain, peripheral ischemia, postural dizziness & hypotension; dry mouth, thirst, altered bowel habits, dyspepsia, gastritis, gingival hyperplasia, abdominal pain, dysphagia, flatulence; gynecomastia, increased/decreased wt, skin discoloration, pruritus, angioedema; micturition disorder, nocturia; hepatitis, jaundice, hepatic enzyme elevations; arthralgia, arthrosis, myalgia, back pain; cough, dyspnea, rhinitis, epistaxis; taste perversion, tinnitus, visual disturbances, abnormal vision, conjunctivitis, diplopia, eye pain. Hydrochlorothiazide: Fever, weakness; cephalalgia, restlessness; transient cerebral ischemic attacks; sialadenitis, spasms, stomach irritation, cramping, gastric irritation; hyperuricemia, hypokalemia, hyponatremia, hypochloremic alkalosis, hypophosphatemia, hypomagnesemia, hypercalcemia, glucose tolerance impairment, glycosuria, increases in total cholesterol, LDL & VLDL cholesterol & triglycerides; agranulocytosis, aplastic & hemolytic anemia; exfoliative dermatitis, anaphylactic reaction, necrotizing angiitis, photosensitivity, polyarteritis nodosa; glycosuria, interstitial nephritis, renal dysfunction, failure & impairment; icterus; muscle spasm; resp distress; transient blurred vision, xanthopsia.
Drug Interactions
Hydrochlorothiazide: Potentiation of orthostatic hypotension w/ alcohol, barbiturates or narcotics. Increased risk of adverse effects w/ amantadine. Potentiate aminoglycoside nephrotoxicity w/ aminoglycoside antibiotics. Increase availability of thiazide diuretics by decreasing GI motility & stomach emptying rate w/ anticholinergic agents (eg, atropine, biperidine). Oral antidiabetics & insulin. Impaired HCTZ absorption w/ cholestyramine & colestipol resins. Intensified hypokalemia w/ corticosteroids, ACTH. Possible decreased renal excretion & increased myelosuppressive effects w/ cytotoxic agents. Decreased response to pressor amines (eg, adrenaline). Possible increased responsiveness to muscle relaxant w/ nondepolarizing skeletal muscle relaxants (eg, tubocurarine). Increases lithium absorption & may cause lithium toxicity. Reduce diuretic, natriuretic & antihypertensive effects of diuretics w/ NSAIDs including COX-2 inhibitors. Additive effect w/ other antihypertensive drugs.
MIMS Class
Calcium Antagonists / Diuretics
ATC Classification
C08GA02 - amlodipine and diuretics ; Belongs to the class of calcium-channel blockers in combination with diuretics. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Amvasc Plus 10/12.5 mg tab
Packing/Price
30's (P31.25/tab)
Form
Amvasc Plus 5/12.5 mg tab
Packing/Price
30's (P19.22/tab)
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